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The perform of SIK1 in tumorigenesis. SIK1 can be a tumor suppressor gene, which plays an important regulatory role in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and affects cancer cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 may also boost most cancers mob